Co-silencing of FAM27E3 and TP53 (siFAM27E3 + siTP53 group) could partially reverse the phenotypic inhibition effect: clone formation and invasion and metastasis ability were restored to about 80% of that of the control group, indicating that FAM27E3’s promotion of cancer is partly dependent on p53 functional inactivation (Figures 10C–E). This evidence concerns the gene TP53 and cancer.