MAPT and Alzheimer disease: Alzheimer’s disease (AD) is twice as prevalent in females (Ferretti et al., 2020; Beam et al., 2018), which may be somewhat associated with differences in lifespan; however, females may have more neurofibrillary tangle pathology and elevated cerebrospinal fluid total tau and Aβ42 levels compared to males (Koran et al., 2017).