In total, 15 statistically significant loci were identified in or near eight genes: DMD, TBX22, LOC101928437, TENM1, SPANXN1, ZFP92, RAC1P4, and AFF2. The next AD XWAS (N = 729,512) employed three independent AD studies and included both a sex-stratified analysis and meta-analysis (Simmonds et al., 2024). This evidence concerns the gene SPANXN1 and Alzheimer disease.