Mitochondrial quality control and dynamics—regulated by dynamin-related protein 1 (DRP1), mitofusins 1 and 2 (MFN1/2), optic atrophy 1 (OPA1), and the PTEN-induced kinase 1/parkin RBR E3 ubiquitin protein ligase (PINK1/Parkin) pathway—are critically important in MASLD pathogenesis [159–161]. Here, PINK1 is linked to metabolic dysfunction-associated steatotic liver disease.