This leads to increased expression of pro-inflammatory cytokines and chemokines such as TNF, interleukin 6 (IL6), interleukin 1β (IL1B), and C-C motif chemokine ligand 2 (CCL2), the molecules tightly linked to MASLD progression and fibrosis [187]. This evidence concerns the gene IL1B and metabolic dysfunction-associated steatotic liver disease.