IL6 and microtia: We performed gene therapy in pregnant mice on the fourth day of pregnancy using AAV-IL-6 at escalating doses to prevent microtia (Figure 10A), and treatment groups were designated as AAV-IL-6-E1 (low dose, 5 × 1010 GC), AAV-IL-6-E2 (medium-low dose, 1 × 1011 GC), AAV-IL-6-E3 (medium-high dose, 3 × 1011 GC), and AAV-IL-6-E4 (high dose, 5 × 1011 GC), respectively.