Saliva-derived EVs from patients with HPV-driven oropharyngeal cancer (OPC) contain detectable HPV16 DNA and exhibit elevated expression of six key glycolytic pathway enzymes: aldolase (ALDOA), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), lactate dehydrogenase A (LDHA), lactate dehydrogenase B (LDHB), phosphoglycerate kinase 1 (PGK1), and pyruvate kinase M1/2 (PKM). This evidence concerns the gene LDHA and oropharynx cancer.