Precisely, in the top panel of Figure 1 the three profiles correspond to values of the rates set to 0%, 30%, and 60% of the corresponding physiological values, while the second panel from the top shows how the whole network is affected by a complete mutation of KRAS. In the third panel we compared this latter profile with the one associated to another frequent mutation in CRC, i.e., the LoF of PTEN, which belongs to the distinct PI3K/PTEN/AKT pathway. The gene discussed is KRAS; the disease is colorectal carcinoma.