The proposed model has been used to simulate the functional alterations induced on the CR-CRN by some of the mutations more commonly found in CRC, including the GoF of genes PI3K, KRAS, and BRAF, and the LoF of genes PTEN, AKT, and TGFβRII (Sommariva et al., 2021a; Sommariva et al., 2021b; Biddau et al., 2023), and a first attempt in modelling the action of Dabrafenib, a drug targeting BRAF, has been performed by Sommariva et al. (2021b). Here, PIK3CA is linked to colorectal carcinoma.