PTEN and colorectal carcinoma: In the present study the mathematical model has been applied in order to analyze the reaction of the network to a GoF mutation of KRAS, a LoF of PTEN, the combination of the two mutations, and a partial GoF mutation of KRAS. The interest toward mutations of KRAS and PTEN comes from the observation that they have been found in approximately 40% and 34% of all CRC cases, respectively (Salvatore et al., 2019; Zhu et al., 2021).