BRAF and colorectal carcinoma: It has been estimated that five to ten tumor-specific driver mutations usually concur in individual cancers and that the most frequent alterations in CRC pertain to TP53, APC, KRAS, PTEN, SMAD4, PIK3CA, BRAF, and AKT (Tortolina et al., 2015; Tariq and Ghias, 2016; Anderson et al., 2019).