There was a case of co-existing p.Glu709Lys and p.Gly719Ala alterations in EGFR. Besides we found one case with co-mutations in EGFR and BRAF genes (EGFR L858R + BRAFc1799T>A) and one NSCLC harboring EGFR c.2235_2249del (p.Glu746_Ala750del) combined with MET amplification. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.