Univariate logistic regression identified significant risk factors for SSI, including diabetes (P < 0.01), smoking (P = 0.043), alcohol (P = 0.022), BMI (P < 0.001), SLSI (P < 0.001) and various systemic immune-inflammation biomarkers such as, CRP, SII, and AISI (all P < 0.001) (Table 1). The gene discussed is CRP; the disease is diabetes mellitus.