One study found that uNAG levels were higher in DN patients than in T2DM patients, suggesting that urinary NAG may be an early indicator of disease progression from T2DM to DN (44), KIM-1, MCP-1, and NAG have been identified as the most promising urinary biomarkers for early diagnosis of renal involvement in IgA vasculitis (45). This evidence concerns the gene HAVCR1 and type 2 diabetes mellitus.