At the same time, comparative serum proteomic analysis showed that levels of heat shock protein 90β family member 2 (HSP90B2) and α1-antitrypsin (AAT) were elevated in CKD patients compared to healthy individuals, and these levels correlated positively with known clinical markers, suggesting that they could serve as novel CKD biomarkers (94). The gene discussed is SERPINA1; the disease is chronic kidney disease.