METTL1 is aberrantly elevated in acute myeloid leukemia (AML) and drives leukemogenesis by enhancing tRNA m7G modification, stabilizing tRNA to promote translation efficiency and cell proliferation, while its depletion disrupts these processes and induces apoptosis, highlighting its potential as a therapeutic target in AML (40). The gene discussed is METTL1; the disease is acute myeloid leukemia.