METTL1 and neoplasm: Further research demonstrates that METTL1 binds the multi-tRNA synthetase complex (MSC) to enhance tRNA aminoacylation efficiency, alleviating translation limitation induced by AKT activation and thereby supporting protein synthesis and tumor growth, revealing the molecular basis for METTL1’s non-canonical, methyltransferase-independent role in promoting sarcomagenesis (34).