In HCC with insufficient radiofrequency ablation (iRFA), METTL1 enhances translation of Snail Family Transcriptional Repressor 1(SNAIL1) and Snail Family Transcriptional Repressor 2(SNAIL2), key epithelial-mesenchymal transition (EMT) regulator, thereby driving heat stress-induced metastatic progression (60). The gene discussed is SNAI2; the disease is hepatocellular carcinoma.