To further investigate whether VEGFR3 inhibition exacerbates LPS-induced neuronal damage and the development of depression-like behaviors, we examined the expression of the synaptic marker PSD95 in the hippocampus and assessed behavioral changes in mice using the open-field test, FST and TST 24 h after i.c.v. injection of LPS. Here, DLG4 is linked to major depressive disorder.