Therefore, in this study, we established a mouse ischemia-reperfusion model to assess the cardioprotective effects of vericiguat by measuring the myocardial infarction area, the apoptosis rate of cardiomyocytes, and the levels of myocardial markers such as creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH), and cardiac troponin I (cTnI). This evidence concerns the gene TNNI3 and myocardial infarction.