However, since Ig are common neo-antigens in B-cell malignancies and Ig-derived neoantigen presentation by MHC is a general phenomenon in lymphomas including DLBCL (Khodadoust et al., 2019), archetype 3 may limit the production of Ig in the context of retained MHC expression to avoid displaying neo-antigen Ig to the immune system (Han et al., 2022a). Here, HLA-C is linked to diffuse large B-cell lymphoma.