However, while mild oxidative stress was found to upregulate TCTP, strong oxidative stress was found to downregulate its expression (Lucibello et al., 2011), and both CKS2 and TPT1 were downregulated in a butyrate resistant cell line conferring tumorigenesis, apoptosis and stress resistance in a colon adenocarcinoma model (López de Silanes et al., 2004). The gene discussed is CKS2; the disease is colon adenocarcinoma.