CXCL2 and chronic obstructive pulmonary disease: Differential expression analysis revealed several DEGs in the COPD lung data, specifically, higher transcript abundances of Macrophage CXCL2 (p < 0.001), Epithelial CXCL1 (p < 0.01), and Neutrophil CXCL8 (p < 0.05) compared to healthy lung (Supplementary Figure 1B).