Hu et al. (2022) found that the novel protein GSPT1-238aa, encoded by circGSPT1, suppresses the growth of GC tumors, suggesting, it may be a special therapeutic target. Circ-MTO1, another circRNA, has been linked to enhanced chemotherapeutic sensitivity, longer DFS, and decreased lymph node metastases in GC (Chang et al., 2022). Here, GSPT1 is linked to gastric cancer.