Genes involved in APL variants reviewed include:ZBTB16, NPM, NuMA, STAT5B, PRKAR1A, FIP1L1, BCOR, NABP1, TBLR1, GTF2I, IRF2BP2, FNDC3B, ADAMTS17, STAT3, and TFG (5), TTMV (6, 7), NUP98 (8), HNRNPC (9, 10), LBD (11), OBFC2A (12), THRAP3 (13), CPSF6 (14), TBL1XR1 (15). The gene discussed is ZBTB16; the disease is acute promyelocytic leukemia.