Furthermore, a different preclinical study shown that exercise in conjunction with PD-L1 immune checkpoint suppression lowered tumor burden, slowed tumor growth, decreased myeloid-derived suppressor cell (MDSC) presence, and increased NK cell activity (185), By producing programmed death-ligand 1 (PD-L1), which interacts with cytotoxic immune cells’ PD-1 to prevent their activation and activity, MDSCs have immunosuppressive effects inside the TME. Here, CD274 is linked to neoplasm.