MTOR and cancer: Alongside decreased signaling through important cell growth pathways, such as decreased phosphorylation of Akt, mTOR, p70S6 kinase (p70S6K), and eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1), there was also an increase in AMPK activation (284), This implies that the mechanisms controlling glucose homeostasis within cancer cells are modulated by physical activity.