Epidermal growth factor receptor (EGFR) is highly expressed in various solid tumors such as hepatocellular carcinoma, non-small cell lung cancer, and breast cancer, which promotes the development, metastasis, and invasion of hepatocellular carcinoma by enhancing the downstream signal, increasing mutation frequency and activating abnormal bypass, leading to poor prognosis (25–27). Here, EGFR is linked to hepatocellular carcinoma.