Mechanistically, copper intracellular transport promoted by electrochlorohydrin upregulates SEC14L3 expression, which, in turn, enhances FDX1 expression via the ERK/YY1 axis, induces thiooctylation of DLAT, triggers its oligomerization, and ultimately leads to cell death and the inhibition of HCC growth (137). The gene discussed is FDX1; the disease is hepatocellular carcinoma.