CD3+CD4+IFN-γ+ helper T lymphocyte (Th1) polarization is demonstrated by the increase in serum IFN-γ and IL-2 in ITP patients, and the Th1/Th2 ratio of T cells in the circulation and spleen is increased (7, 8). This evidence concerns the gene IFNG and autoimmune thrombocytopenic purpura.