HERC6 and systemic lupus erythematosus: In Figure 6F, in the SLE dataset GSE81622, the expression levels of HERC6, IFI44L, and RSAD2 were significantly higher in SLE patients compared to the control group (P<0.05); whereas the gene expression level of PIK3IP1 was significantly lower in SLE patients compared to the control group (P<0.05).