MUC1 and neoplasm: We and others have found the expression of TAAs, including PSCA and MUC1, to be similar between 3D models and tumor xenografts, and tumor spheroids present a bulk mass that recapitulates the solid tumor architecture and tumor-produced extracellular matrix, which is well suited for initial preclinical screening of complex therapeutics, as assessed in the current study (40, 53, 54).