Among them, interactions mediated by PDCD1LG2-PDCD1, NCR3LG1-NCR3, ICOSLG-ICOS, HLA-F-VSIR, HLA-E-VSIR, CD86-CTLA4, CD86-CD28, CD80-NGFR, CD80-CTLA4, CD80-CD28, CD276-TREML2, CD274-PDCD1, CD274-CD80 were observed between tumor cells and stromal cells. This evidence concerns the gene CD28 and neoplasm.