Furthermore, Gulla et al. demonstrated in another study that mice with melanoma showed a significant survival rate exceeding 75% when treated with AuNPs-CGKRK peptide (ranging from 17 to 80 nm) in combination with SiRNA-PDL-1 and STAT3 SiRNA genes, outperforming individual AuNPs and genes used [91]. Here, STAT3 is linked to melanoma.