SULT2A1 and acne: An excess in androgen levels is responsible for many of the physical symptoms of PCOS, including hirsutism, acne, and hair loss, and the cumulative evidence presented here indicates statin therapy can significantly reduce both free and total testosterone levels as well as DHEAS and androstenedione (Rashidi et al., 2011; Seyam et al., 2018; Pourmatroud et al., 2015; Seyam and Hefzy, 2018; Kazerooni et al., 2010; Kaya et al., 2010; Kaya et al., 2009; Duleba et al., 2006; Krysiak et al., 2014; Banaszewska et al., 2007).