Improved spontaneous menses per 6 months, ovulation, volume of both ovaries, waist/hip ratio, hirsutism score, acne, total T, free T, DHEAS, SHBG, LH/FSH ratio, prolactin, total cholesterol, LDL, HDL and triglycerides. No AEs. The gene discussed is SHBG; the disease is Hirsutism.