The overexpression of certain collagen genes (COL1A1 and COL1A2) in RCC suggests a role in extracellular matrix (ECM) remodeling (Devos et al., 2023), a critical factor in tumor metastasis (Piersma et al., 2020), as well as in the structural changes observed in glaucoma (Agarwal and Iezhitsa, 2023). The gene discussed is COL1A2; the disease is glaucoma.