Additionally, we demonstrated that aprepitant modulates the expression of multiple key genes and proteins involved in glioma progression, including VEGF, NF‐kB, TNF‐α, IL‐6, IL‐8, CCL3, CXCL3, and TRIM5, indicating its potential to suppress glioma‐associated angiogenesis, inflammation, and chemotaxis. This evidence concerns the gene NFKB1 and central nervous system cancer.