I. obliquus has been shown in the literature to induce apoptosis in various cancer cell lines via multiple mechanisms, including mitochondrial membrane depolarization, cell cycle arrest, and the upregulation of proapoptotic proteins such as Bax and caspase-3, while downregulating anti-apoptotic B-cell lymphoma 2 (Bcl-2) expression [1,6,8,11,12,14,15,61,64,73,75,77,78,79]. This evidence concerns the gene BCL2 and cancer.