NFKB1 and hepatocellular carcinoma: Further research by Hu et al. elucidated the multifaceted bioactivities of toon-derived limonoids, including potent antioxidant effects via free radical scavenging, anti-inflammatory action mediated by NF-κB pathway suppression, and selective cytotoxicity toward HepG2 hepatocellular carcinoma cells [26].