Several hypotheses have been proposed to explain its pathogenesis, including the cholinergic hypothesis, which attributes cognitive decline to the loss of cholinergic neurons and reduced acetylcholine levels; the tau hypothesis, which involves the aggregation of hyperphosphorylated tau proteins into neurofibrillary tangles; and the neuroinflammatory hypothesis, which emphasizes chronic neuroinflammation driven by activated microglia and astrocytes [3,4,5]. Here, MAPT is linked to Mental deterioration.