TNF and neoplasm: In BC cells, the signaling pathways TNFα/NFκB and IL6/STAT3 are known to promote tumor progression via activation of key EMT-related transcription factors, such as Snail Family Transcriptional Repressor 1 (Snail1), Twist-related protein 1 (Twist1), and Zinc finger E-box binding homeobox 1 (ZEB1) [9,10,11,12,15,16,17,18].