In vivo and in vitro tests have shown that 4-chloro-3,5-dimethoxybenzoic methyl ester and erinacine A stimulate nerve growth factor (NGF) synthesis and nerve regeneration in a Sprague–Dawley rat model and may be an important therapeutic element in alleviating the effects of neurodegenerative diseases, such as Parkinson’s and Alzheimer’s disease. This evidence concerns the gene NGF and Alzheimer disease.