In the study by Parida et al. (2024) [145] in insulin-resistant human SK-N-SH neuroblastoma, it was found that DNJ increased the expression of insulin signaling genes and the phosphorylation status of key molecules implicated in insulin resistance (Y1146-pIRβ, S473-pAKkt, S9-GSK3B) and also increased the expression of glucose transporters GLUT3 and GLUT4, resulting in higher glucose uptake upon insulin stimuli. The gene discussed is INS; the disease is Insulin resistance.