In models of intestinal inflammation, FFAR4 agonism enhances IL-10 production by CD4+ T cells: treatment with the selective agonist CpdA upregulates Blimp1 and glycolysis via mTOR, increasing IL-10 and protecting mice from Dextran sulfate sodium (DSS)-induced colitis, whereas GPR120-deficient T cells exacerbate disease. Here, IL10 is linked to inflammation.