NFKB1 and Alzheimer disease: Additionally, G. lucidum polysaccharides have been shown to protect against neurodegeneration in conditions such as AD and epilepsy by regulating OS-associated signaling pathways, including extracellular signal-regulated kinase/protein kinase B, c-Jun N-terminal kinase/mitogen-activated protein kinase, and NF-κB [70,93].