This is consistent with the data of So et al., who cultured the human colorectal cancer cell line HCT116 with resistance maltodextrin (FIbersol-2) and found that Fibersol-2 significantly suppressed tumor growth of HCT116 cells by inducing apoptosis, inducing mitochondrial ROS and Bax-dependent cleavage of caspase 3 and 9, and phosphorylation of Akt/mTOR [98]. This evidence concerns the gene BAX and colorectal cancer.