In a recent study, we have shown that the curcumin-induced cytotoxic effect against colon cancer cells correlated with the downregulation of methyltransferases such as enhancer of Zeste 2 Polycomb repressive complex 2 Subunit (EZH2), G9a, and mixed lineage leukemia protein-1 (MLL-1). The gene discussed is EZH2; the disease is colonic neoplasm.