TNF and cystic fibrosis: (-308 GA, rs1800629) polymorphism is associated with CF [124]. +691g ins/del polymorphic locus is associated with the severity of lung disease and. aeruginosa infection [144]. TNFα -308GA promoter polymorphism (rs1800629) that were associated with high TNFα transcription, CF and AKI severity [145,146,147].