The search included combinations of the following keywords: “Cystic fibrosis,” “kidney injury,” “biomarkers,” “chronic kidney disease (CKD),” “acute kidney disease (AKD),” “CF-related kidney disease (CFKD),” and “CFTR.” We included original research articles, reviews, and clinical studies that focused on biomarkers associated with kidney disease in people with cystic fibrosis, as well as in the general population to offer a comprehensive view of the current biomarker landscape. This evidence concerns the gene CFTR and kidney disorder.