Takizawa et al. used a Tim4-based ELISA to measure uEV markers, including distal tubule/collecting duct-specific Mucin 1 (MUC1) and proximal tubule-specific maltase-glucoamylase (MGAM), showing the MGAM/MUC1 ratio rises as kidney function declines in CKD patients [105]. The gene discussed is MGAM; the disease is chronic kidney disease.