Anti-Ro/SS-A antibodies, autoantibodies detected in two-thirds of patients with SjD [38], are included in all of the four classification/diagnostic criteria for SjD [12,13,14,21,29], whereas anti-La/SS-B antibodies, the isolated positive detection of which was reported as not useful for the diagnosis of SjD [39] and even other autoimmune diseases [38], are not included in the 2016 ACR/EULAR classification criteria [13,14]. Here, CALR is linked to autoimmune disease.