Moreover, there were statistically significantly higher complication rates of physical manifestations including lymphadenopathy; Raynaud’s phenomenon; vasculitis; neurological involvement; arthritis; organ involvement, including interstitial lung disease and autoimmune thyroiditis; and hematological abnormalities, including cytopenia and hypergammaglobulinemia, in the patient group positive for all four autoantibodies compared to the patient group positive for anti-Ro/SS-A antibodies and ANA and the patient group positive for none of the four antibodies [42]. The gene discussed is CALR; the disease is Lymphadenopathy.