Indeed, the Apnea Hypopnea Index (AHI) and blood oxygen desaturation in OSA are associated with CRP levels [63,64,65] and, with only a few exceptions [66], epidemiological OSA investigations and a meta-analysis including 15 studies showed elevated CRP and TNF-α levels [67,68,69,70]. This evidence concerns the gene CRP and obstructive sleep apnea syndrome.