Also, experimentally induced SF with reduced slow-wave (i.e., deep) sleep duration impairs insulin sensitivity [29,30] in healthy humans and is associated with insulin resistance independent of age and obesity when combined with IH [31], while, in people with OSA or T2DM, is negatively affects glucose homeostasis [32,33,34,35,36]. The gene discussed is INS; the disease is type 2 diabetes mellitus.