Another limitation of this study is that we could not include the mean arterial blood pressure, nor biochemical markers such as pregnancy-associated plasma protein A, soluble Fms-like tyrosine kinase-1, and placental growth factor, or their ratio, in combination with uterine artery Doppler measurements to create predictive models for the development of preeclampsia. The gene discussed is FLT1; the disease is preeclampsia.