Hepatocyte growth factor (HGF), secreted protein acidic and cysteine-rich (SPARC), a disintegrin and metalloproteinase 12 (ADAM12), and matrix metallopeptidase 8 (MMP8) were identified as biomarkers with significant roles in inflammatory processes and immune dysregulation, contributing to both IBD and MDDs. This evidence concerns the gene HGF and inflammatory bowel disease.