At least two of the following four criteria must be met for diagnosis: clinical signs such as hepatosplenomegaly, biochemical abnormalities like persistently elevated liver enzymes (e.g., Aspartate transaminase (AST), Alanine transaminase (ALT), Gamma-glutamyl transferase (GGT), radiologic evidence from ultrasound (e.g., signs of portal hypertension or biliary tract abnormalities), or histological confirmation of fibrosis or cirrhosis [13]. The gene discussed is GPT; the disease is portal hypertension.