Among these, SDC1 was the only independent predictor of both AKI onset (OR: 1.201; 95% CI: 1.025–1.406; p = 0.024) and RRT initiation (OR: 1.260; 95% CI: 1.078–1.472; p = 0.004), whereas NGAL retained significance only in univariable analyses. Here, SDC1 is linked to acute kidney injury.