In two patients with CF who presented with neonatal cholestasis syndrome, the CFTR variants c.(53+1_54-1)_(164+1_165-1)del (CFTRdele2) and c.54-5940_273+10250del (CFTRdele2,3 (21kb)) were identified, in both cases with a compound heterozygous genotype, with the other allele being F508del (Table 1). This evidence concerns the gene CFTR and cystic fibrosis.