Combined immunodeficiencies alongside syndromic characteristics were associated with pathogenic mutations in DOCK8, STAT3, WAS, ATM, and TBX1, which included an autosomal dominant STAT3 variant (c.1144C>T; p.Arg382Trp) and an X-linked WAS variant (c.271C>T). Here, DOCK8 is linked to Wiskott-Aldrich syndrome.