The cytokine profiles of COVID-19 and IPF show significant overlap, particularly in the elevation of profibrotic and proinflammatory mediators such as transforming growth factor-beta (TGF-β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). This evidence concerns the gene TGFB1 and idiopathic pulmonary fibrosis.