In 60 patients who underwent tumour excision (laparoscopic or laparotomic adrenalectomy was decided depending on the tumour size), pre-operatory hypercortisolism was confirmed based on having ≥ 3 criteria out of the followings: plasma cortisol after 1 mg DST > 3 μg/dL, UFC > 60 mg/24 h, ACTH < 10 pg/mL, and MSC > 5.4 mg/dL. The gene discussed is POMC; the disease is neoplasm.