While we found no distinct genetic data [31,32,33,34,35,36,37,38,39,40,41,42,43,44] across the mentioned studies, on a deeper level, sporadic unilateral NFAs and MACS-positive adrenal tumours present similar genomic and transcriptome characteristics, distinguishing them from adrenal CS [85,86,87], with the most prevalent genetic aberration being a somatic CTNNB1 pathogenic variant that activates the Wnt-β–catenin pathway [87,88]. This evidence concerns the gene CTNNB1 and adrenal gland neoplasm.