POMC and Adrenal insufficiency: Although postoperative biochemical testing frequently reveals abnormalities consistent with an adrenal insufficiency, their associated clinical significance and if low serum cortisol measurements and/or a blunted response to ACTH stimulation should pinpoint starting glucocorticoids replacement, or whether these patients can be safely followed without steroids exposure if they do not exhibit clear symptoms/signs of an adrenal failure are unclear [109,110].