In addition to CNL, CSF3R alterations are frequently seen in atypical chronic myeloid leukemia (aCML), also known as myelodysplastic/myeloproliferative neoplasm with neutrophilia (MDS/MPN-N), and severe congenital neutropenia (SCN) [10,11]. The gene discussed is CSF3R; the disease is chronic neutrophilic leukemia.