Beyond miRNAs, extracellular vesicles (EVs) function as key carriers of miRNAs, proteins and lipids between airway epithelial/immune cells and microbes; their cargo and release are altered in asthma (e.g., IL-13-induced epithelial EVs and higher serum EV miR-125b/miR-126), and blocking exosome biogenesis mitigates experimental airway inflammation, underscoring diagnostic and therapeutic potential [170]. The gene discussed is IL13; the disease is asthma.