ORMDL3 and asthma: Notably, the expression of ORMDL3 (encoding ORMDL sphingolipid biosynthesis regulator 3) and GSDMB (encoding gasdermin B), both asthma-associated genes located in the 17q21 locus, was significantly elevated in RV-stimulated peripheral blood mononuclear cells (PBMCs) compared to unstimulated PBMCs [66].